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Abstract: Mushroom extracts are known to be good sources of antiviral agents (GOULET et al, 1960), as has been visualized by COCHRAN'S group in the United States. In 1969 (TSUNODA and ISHIDA, 1970) we noticed the antiviral activity of the aqueous extract of Lentinus edodes, a kind of Japanese edible mushrooms, against influenza A/SW-15 virus infection in mice, during the screening of aqueous extracts of various kinds of Japanese mushrooms by COCHRAN'S method (COCHRAN et al., 1967). Thereafter, the phenol extract of the spores was found to be more effective than that of the fruit-bodies. This report presents the evidence that the antiviral activity of the spore extract can be ascribed to interferon induction and the principal component for interferon induction is the double-stranded RNA contained in the spore extract.
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