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Abstract: It has long been taught by many pathologists that aging of the human body starts with the blood vessels. It must have been a conclusion arrived at after many years of human anatomy and tissue sample studies. It is a known fact that the blood vessels of the aged are harder than those of the youth, and they become harder as a man advances in age. Moreover, it was found that the hardening of the blood vessels takes place prior to aging of other organs. Because nutrition of the human tissues throughout the body is supplied by the blood flowing through the blood vessels, it would be quite natural to assume that the hardening and narrowing of vessels causes poorer and poorer delivery, and therefore, results in aging of the tissues. Based on these facts and reasonable assumptions, prevention of blood vessel hardening is the key to keep the body young. In essence, hardening of the vessels is regarded as representing aging. In addition, myocardial-infarction due to hardening coronal arterien and cerebral embolus or encephalomalacia caused by hardening brain blood vessels occupy one of top-ranking causes of death in the Japanese in recent years. indeed, death due to the above conditions accounts for approximately onehalf of the total deaths in the middle-aged and aged group. Prevention and cure of atherosclerosis is now one of the most important problems to be worked out in the national health program. In our Institute, we took this up among others after the war, made surveys in the cities and out in the country, and have been performing animal experiments and human experiments with respect to the effectiveness of foods on hardening of the blood vessels. The Shii-ta-ke has been repeatedly tested on humans since February, 1967. Professor KANEDA (KANEDA et al, 1964) of Tohoku University made animal experiments and stated in his report that Shii-ta-ke was found to prevent high serum cholesterol in albino rats three years before we started our experiments. We, therefore, conducted experiments to see whether such effect would also be applicable to humans, because the degree of effectiveness of foods and drugs in controlling blood vessel hardening varies considerably among animal species-responses to the foods and drugs by the animal species are not all the same.
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