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Abstract: At the London's meeting in 1971, we reported that Shii-ta-ke, Lentinus edodes, could remarkably reduce plasma cholesterol levels in rats (KANEDA et al, 1964; TOKITA et al, 1971). Later the hypocholesterolemic substance was isolated from Shii-ta-ke by other Japanese workers and was named Eritadenine (CHIBATA et al, 1969; KAMIYA et al, 1969) (Fig. 1). However, no definite information is available on the plasma cholesterol reducing mechanism by Eritadenine or Shii-ta-ke. An attempt has been made in the present study to elucidate the reducing mechanism of plasma cholesterol by Shii-ta-ke.
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