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Abstract: Wet bubble, a kind of mushroom disease caused by Mycogone perniciosa MAGN, has become a serious problem following the increased cultivation of mushrooms in Taiwan. For years, studies have been made of this disease and are now encouraged to develop into the applicatory. According to CONSTANTIN and DUFOUR (1892) and VEIHMEYER (1914), the symptom of the disease was possibly caused by the mixture of various Verticillium sp. In 1924, SMITH described the symptom in detail after an extensive study of the disease. In 1928, BEACH reported the relationship between the causal organism and the humidity. In 1930, LAMBERT revealed the reaction of the disease. In 1948, ATVINE and TOUCHE disclosed the way of invasion of the causal organism and the transmission of the disease. In 1950, KLIGMAN illustrated the morphology of the organism, causal factors and control methods. In 1961, ZOBERI indicated the influence of wind velocity and humidity on the disease. In 1965, FEKETE and KUHN used two chemicals of perzate (Zine ethlene-bis-dithiocarbamate) and Vertomyc (Manganesezinc ethylene-bis-dithiocarbamate) to control the disease and found Vertomyc more effective than perzate. In 1968, FLETCHER and GANNEY studied the artificial inoculation of the diseases and found that the disease was mostly transmitted by the casing soil while the composts were rare; He suggested the control method of using Formalin and Mancozab. In 1969, CLAUDE reported that the disease might spread out through the contaminated bed due to the picker's basket during the picking. Since the fungicides contained heavy metals such as Zn and Mn which prohibited in developed countries, Dithane M-22 was not used though this chemical was effective in control of the disease as reported in 1969. Thus, up to no chemicals are used to control the disease. We have conducted experiments with the inhibitory effect of some chemicals, both in vitro and in vivo, on the M. perniciosa in order to find out effective ones to control the disease.
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