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Abstract:
Allergy is a common health problem in developed countries.
The incidence of typeⅠallergic disorders has
been increasing worldwide, particularly, hypersensitivity to food and airborne allergens.
The mechanism of
TypeⅠallergy includes a series of events, namely, production of antigen-specific immunoglobulin E (IgE). IgE
synthesis is considered to be caused by development and activation of T helper-2 (Th2) cells and B cells.
This
specific Th2 cell produces predominantly interleukin (IL)-4. In contrast, the T helper 1 (Th1) cells mainly
secrete cytokines such as IL-2 and interferon (IFN)-
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that inhibit IgE and IgG1 secretion and enhance IgG2a
secretion.
Thus, it seems that shifting the balance from Th2 to Th1 dominance should be a rational strategy to
prevent IgE-mediated allergic diseases.
In this study, we examined the effect of Agaricus brasiliensis S.
Wasser et al. (ABSW) on the balance of Th1/Th2.