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Abstract: Waste of Ganoderma tsugae fruiting bodies from a health food factory was treated with 1 N KOH and 1% sodium hypochloride to produce a pulp-like white paste. The paste was filtered and lyophilized to produce sacchachitin, a chitin-containing polysaccharide membrane. A clinical study was carried out on patients suffering from chronic skin ulcers (>10 cm) for at least 6 months. Sacchachitin was applied to one-half of the wound area, while the other half remained uncovered as a control. Among 47 patients, 13 were subjected to matrix metallo-proteinases (MMPs) analysis. Fluids were collected from the sacchachitin-treated and control tissues, and subjected to enzyme-linked immunosorbent assay. Denaturing-gel electrophoretic analysis also was performed to examine the binding of MMPs by sacchachitin. Approximately 85% of the patients showed accelerated healing in the sacchachitin treatment. The increased binding of MMPs by sacchachitin was proposed as the mechanism of action.
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